Publications

2026

Attenuation of epicardial activation and myofibroblast abundance via the Fbln2–Nupr1b axis stimulates cardiac regeneration in zebrafish

Gülsüm Kayman Kürekçi, Gursimran Kaur Bajwa, Shaoqiu Zhang, Séverine Leclerc, Emilie de Chantal, Darrell Belke, Gregor Andelfinger, Justin F Deniset, Rubén Marín-Juez

Immune Cell Regulation of Zebrafish Heart Regeneration

Shaoqiu Zhang, Eliza Sassu, Rubén Marín-Juez

Developmental single-cell atlas of coronary vessel growth and cardiomyocyte interaction in zebrafish

Muhammad Abdul Rouf, Gülsüm Kayman Kürekçi, Shaoqiu Zhang, Stéphanie Larrivée Vanier, Sarah M Kamel, Ann Nee Lee, Ruey-Bing Yang, Shih-Lei Lai, Rubén Marín-Juez

2025

Scube2 Modulates Coronary Vessel Formation during Cardiac Growth and Regeneration in Zebrafish

Ann Nee Lee, Ke-Hsuan Wei, Kaushik Chowdhury, Muhammad Abdul Rouf, An-Ju Chu, Yu-Jen Hung, Ku-Chi Tsao, Yan-Ting Chen, Yuh-Charn Lin, Yao-Ming Chang, Rubén Marín-Juez, Ruey-Bing Yang, Shih-Lei Lai

When the heart calls for help: Clusterin reprograms immunity to enable regeneration

Shih-Lei Ben Lai, Yu-Jen Hung, Rubén Marín-Juez

Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis

Ailen Soledad Cervino, Amrita Basu, Ryan J Weiss, Gursimran Kaur Bajwa, Rubén Marín Juez, Sandra Grimm, Cristian Coarfa, Margot Kossmann Williams

Activation of ankrd1a expression marks newly forming myofibers and regulates muscle cell differentiation in adult zebrafish skeletal muscle repair

Mina Milovanovic, Mirjana Novkovic, Srdjan Boskovic, Rubén Marín Juez, Andjela Milicevic, Jovana Jasnic, Emilija Milosevic, Bojan Ilic, Didier YR Stainier, Snezana Kojic

The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration

Savita Gupta, Gursimran Kaur Bajwa, Hadil El-Sammak, Kenny Mattonet, Stefan Günther, Mario Looso, Didier YR Stainier, Rubén Marín-Juez

2024

flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response

Zhen-Yu Wang, Armaan Mehra, Qian-Chen Wang, Savita Gupta, Agatha Ribeiro da Silva, Thomas Juan, Stefan Günther, Mario Looso, Jan Detleffsen, Didier YR Stainier, Rubén Marín-Juez

The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration

Pinelopi Goumenaki, Stefan Günther, Khrievono Kikhi, Mario Looso, Rubén Marín-Juez, Didier YR Stainier

2022

Modulation of VEGFA signaling during heart regeneration in zebrafish

Kaushik Chowdhury, Shih-Lei Lai, Rubén Marín-Juez

A Vegfc-Emilin2a-Cxcl8a signaling axis required for zebrafish cardiac regeneration

Hadil El-Sammak, Bingyuan Yang, Stefan Guenther, Wenbiao Chen, Rubén Marín-Juez, Didier YR Stainier

2021

Cardiomyocyte heterogeneity during zebrafish development and regeneration

Ayele Taddese Tsedeke, Srinivas Allanki, Alessandra Gentile, Vanesa Jimenez-Amilburu, Seyed Javad Rasouli, Stefan Guenther, Shih-Lei Lai, Didier YR Stainier, Rubén Marín-Juez

2020

Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish

Ryuichi Fukuda, Rubén Marín‐Juez, Hadil El‐Sammak, Arica Beisaw, Radhan Ramadass, Carsten Kuenne, Stefan Guenther, Anne Konzer, Aditya M Bhagwat, Johannes Graumann, Didier YR Stainier

2019

Coronary revascularization during heart regeneration is regulated by epicardial and endocardial cues and forms a scaffold for cardiomyocyte repopulation

Rubén Marín-Juez, Hadil El-Sammak, Christian SM Helker, Aosa Kamezaki, Sri Teja Mullapuli, Sofia-Iris Bibli, Matthew J Foglia, Ingrid Fleming, Kenneth D Poss, Didier YR Stainier

Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model

Michelle M Collins, Gustav Ahlberg, Camilla Vestergaard Hansen, Stefan Guenther, Rubén Marín-Juez, Anna M Sokol, Hadil El-Sammak, Janett Piesker, Ylva Hellsten, Morten S Olesen, Didier YR Stainier, Pia R Lundegaard

Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration

Dana Gancz, Brian C Raftrey, Gal Perlmoter, Rubén Marín-Juez, Jonathan Semo, Ryota L Matsuoka, Ravi Karra, Hila Raviv, Noga Moshe, Yoseph Addadi, Ofra Golani, Kenneth D Poss, Kristy Red-Horse, Didier YR Stainier, Karina Yaniv

Immune responses in cardiac repair and regeneration: a comparative point of view

Shih-Lei Lai, Rubén Marín-Juez, Didier YR Stainier

2018

HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development

Sébastien Gauvrit, Alethia Villasenor, Boris Strilic, Philip Kitchen, Michelle M Collins, Rubén Marín-Juez, Stefan Guenther, Hans-Martin Maischein, Nana Fukuda, Maurice A Canham, Joshua M Brickman, Clifford W Bogue, Padma-Sheela Jayaraman, Didier YR Stainier