Welcome to the

Marin-Juez Lab

What we do

Cardiovascular diseases are the leading cause of death worldwide, with myocardial infarction as the most common cause of heart injury in humans. Understanding why the human heart fails to regenerate and how zebrafish can regenerate theirs highlights the importance of this research for advancing regenerative medicine.

Our laboratory is interested in the cellular and molecular mechanisms regulating cardiac regeneration, with a special focus on the role of the cardiac endothelium in this process. Coronary invasion of the damaged tissue spearheads the regenerative response and is required to support cardiac regeneration. We are interested in understanding how the cardiac endothelium regulates various aspects of cardiac regeneration and development, and how alterations in coronary network formation affect the ability of coronary vessels to support tissue replenishment. We use zebrafish genetic models, molecular biology, histology, in vitro mammalian models, and all that with a good pinch of cool imaging.

Research Overview

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